PDK4 as a tumor suppressor in gastric cancer: implications for metabolic regulation, immune modulation, and prognostic potential
PDK4 functions as a tumor suppressor in GC, bridging metabolic reprogramming, epigenetic regulation, and immune microenvironment remodeling. Its downregulation contributes to disease progression and immune evasion, underscoring its potential as a prognostic biomarker and therapeutic target. Restoring PDK4 activity may serve as a promising strategy to mitigate GC aggressiveness and therapeutic resistance.
Authors
- Wei He (ORCID: https://orcid.org/0000-0001-8909-9008)
- Jie Sun (ORCID: https://orcid.org/0000-0002-2851-9053)
- Nan Sang (ORCID: https://orcid.org/0000-0002-2433-3200)
- Nannan Zhang (ORCID: https://orcid.org/0000-0003-0571-4099)
- Jin Xu (ORCID: https://orcid.org/0000-0002-3735-1045)
- Buwei Teng
Institutions
- Xuzhou Medical College (CN)
- Lianyungang Oriental Hospital (CN)
- The First People’s Hospital of Lianyungang (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1007/s12672-025-03581-1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00