Global Proteoform Alterations Across Multiple Cellular Compartments Underlie Obstructive Hypertrophic Cardiomyopathy
This study represents the most comprehensive analysis of the proteoform landscape in HCM to date, uncovering pathways beyond the sarcomere that may contribute to HCM pathophysiology and identifying potential targets for development of therapeutic interventions.
Authors
- Yanlong Zhu (ORCID: https://orcid.org/0000-0003-4909-7336)
- J. Carter Ralphe (ORCID: https://orcid.org/0000-0001-8116-2324)
- Scott J. Price
- Joshua L. Hermsen
- Holden T. Rogers (ORCID: https://orcid.org/0000-0003-0870-0127)
- Emily A. Chapman (ORCID: https://orcid.org/0000-0003-1110-8984)
- Timothy J. Aballo (ORCID: https://orcid.org/0000-0003-1164-5966)
- B Zhang
- Willem J. de Lange (ORCID: https://orcid.org/0000-0001-7296-8924)
- Timothy J. Kamp (ORCID: https://orcid.org/0000-0003-2103-7876)
- Kalina J. Rossler (ORCID: https://orcid.org/0000-0003-0353-1774)
- Ying Ge (ORCID: https://orcid.org/0000-0001-5211-6812)
- Zachery R. Gregorich (ORCID: https://orcid.org/0000-0002-4013-4869)
- Jiaqi Chen (ORCID: https://orcid.org/0000-0002-4069-193X)
- Zhan Gao (ORCID: https://orcid.org/0009-0009-0677-9653)
Institutions
- University of Wisconsin–Madison (US)
- Regenerative Medicine Institute (MX)
Publication Details
- Journal
- Circulation Heart Failure
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1161/circheartfailure.125.012899
- Citations
- 1
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.39