Monte Carlo-based subcellular comparison of electron energy deposition by 177Lu and 161 Tb: implications for targeted radiopharmaceutical therapy
<sup>161</sup> Tb offers a more efficient subcellular energy deposition profile than <sup>177</sup>Lu. It enables either similar therapeutic effect with fewer decays or enhanced nuclear absorbed dose under equivalent bone marrow toxicity. These results support the use of <sup>161</sup> Tb in targeted radiopharmaceutical therapy, particularly for isolated tumor cells and micrometastases.
Authors
- Alexandre França Velo (ORCID: https://orcid.org/0000-0001-9786-4136)
- John L. Humm (ORCID: https://orcid.org/0000-0003-4245-5591)
- Lucas Carter (ORCID: https://orcid.org/0000-0003-0385-9833)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
Publication Details
- Journal
- EJNMMI Physics
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s40658-025-00810-y
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Cancer Institute