The DNA Vaccines for the Gn and Gc Heterologous Polymer of Severe Fever with Thrombocytopenia Syndrome Virus Induce Potent Immunogenicity in Mice
The DNA vaccines encoding dimer or hexamer-2 demonstrated superior immunogenicity over other conformations, after taking the results of humoral and cellular responses into account. This study revealed the advantages of using polymer conformations in SFTSV vaccine design and provided new targets in SFTSV vaccine development.
Authors
- Jincheng Tong
- Zhi‐Hua Li (ORCID: https://orcid.org/0000-0002-6484-657X)
- Mengyi Zhang (ORCID: https://orcid.org/0000-0002-7340-6648)
- Heng Zhang (ORCID: https://orcid.org/0000-0003-2734-2193)
- Qianqian Li (ORCID: https://orcid.org/0000-0001-6961-771X)
- Xiaojuan Liu (ORCID: https://orcid.org/0000-0001-7577-2943)
- Huan Li (ORCID: https://orcid.org/0000-0002-7382-6546)
- Jiamin Chen (ORCID: https://orcid.org/0009-0006-3768-4575)
- Qiuju He (ORCID: https://orcid.org/0009-0006-5415-4832)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Vaccines
- Published
- 2025-11-24
- DOI
- https://doi.org/10.3390/vaccines13121186
- Primary Topic
- Viral Infections and Vectors
- Type
- article
- Field-Weighted Citation Impact
- 0.00