IFN-γ and IL-22 in premature ovarian insufficiency correlation with ovarian reserve markers and pathogenic implications: a cross-sectional study
POI features a unique immunocytokine signature with elevated IFN-γ/IL-22 that correlates with ovarian reserve depletion and shows diagnostic promise. The dissociation between menstrual cyclicity and cytokine patterns implies distinct endocrine-immune pathophysiological mechanisms, positioning these cytokines as potential biomarkers for POI diagnosis and mechanistic research.
Authors
- Rong Hua
- Xiao Jiang (ORCID: https://orcid.org/0000-0003-1280-800X)
- Fengqiong Liu (ORCID: https://orcid.org/0000-0001-7786-7305)
- Jing Liang (ORCID: https://orcid.org/0009-0004-6068-9732)
- Qing Liu (ORCID: https://orcid.org/0000-0003-2745-3440)
- Fengzhang Lv
- Xin Liu (ORCID: https://orcid.org/0000-0003-3256-2940)
- Min He
- Yan Sun (ORCID: https://orcid.org/0000-0002-8902-8661)
- Menghan Lu (ORCID: https://orcid.org/0000-0002-9993-6794)
Institutions
- Guangxi Zhuang Autonomous Region Health and Family Planning (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
- Guangxi Maternal and Child Health Hospital (CN)
Publication Details
- Journal
- BMC Women s Health
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s12905-025-04113-3
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00