Capillary leak syndrome in sepsis: the role of intrinsic coagulation pathway activation
APTT is a sensitive indicator for predicting SACLS. APTT prolongation in plasma might be attributable to the enrichment of FXII in the microcirculation. The microcirculatory enrichment of FXII might activate the kinin and complement systems, contributing to the process of capillary leakage.
Authors
- Chen Yun-fen
- Jin-Lian Jiang
- Yi-Huai He (ORCID: https://orcid.org/0000-0002-8639-3436)
- Xue Xiao (ORCID: https://orcid.org/0000-0003-1666-3813)
- Ya Chen (ORCID: https://orcid.org/0000-0001-7643-919X)
- Zhong-Qin Pan
- Shu Li (ORCID: https://orcid.org/0000-0003-0183-5459)
- Huan Chen (ORCID: https://orcid.org/0000-0003-1182-3144)
- Yinghua Chen (ORCID: https://orcid.org/0000-0003-2295-7228)
- Weiwei Zhong
Institutions
- Zunyi Medical University (CN)
- First People’s Hospital of Jingmen (CN)
- Suizhou Central Hospital (CN)
- First People’s Hospital of Zunyi (CN)
- Kaili University (CN)
- Affiliated Hospital of Zunyi Medical College (CN)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s12879-025-12069-w
- Citations
- 2
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 3.09