Photoredox-Catalyzed Aminosulfonylation of <i>gem</i> -Difluoroalkenes via the Ritter Reaction

A photocatalytic aminosulfonylation reaction of <i>gem</i>-difluoroalkenes, sulfonyl chlorides, and nitriles was successfully developed through a three-component Ritter-type reaction, with nitriles serving as both reactants and solvents. This efficient difunctionalization protocol is allowed for the synthesis of α,α-difluoromethyl-β-amidesulfonyl compounds in one step under mild conditions. The reaction exhibited broad functional group compatibility and particularly good reactivity with various nitriles. These products can be used as platform molecules for further modification. A possible mechanism was also proposed based on mechanistic experiments.