EZH1 Inhibition attenuates apoptosis and promotes regeneration for liver repair in acute liver failure
Our findings identify EZH1 as a pivotal epigenetic regulator promoting hepatocyte apoptosis in ALF. Targeted inhibition of EZH1 may offer a promising therapeutic approach to restore the balance between hepatocyte death and regeneration, thereby facilitating liver repair.
Authors
- Yili Chen (ORCID: https://orcid.org/0000-0001-8455-9378)
- Meihua Mei
- Xiao Cong (ORCID: https://orcid.org/0000-0002-1867-9571)
- Junqi Huang (ORCID: https://orcid.org/0000-0002-0901-9635)
- Ning Tan (ORCID: https://orcid.org/0009-0001-0589-5822)
- Feng Gu (ORCID: https://orcid.org/0009-0006-8207-678X)
- Peidong Chi (ORCID: https://orcid.org/0000-0002-9838-2590)
- Ying You
Institutions
- Sun Yat-sen University (CN)
- Key Laboratory of Guangdong Province (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s12876-025-04463-0
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00