Prediction of prognostic biomarkers for hepatocellular carcinoma and immune microenvironment infiltration based on single-cell sequencing and RNA-Seq integration
This study identified and validated prognostic biomarkers in HCC that effectively predict patient survival rates and immune infiltration characteristics. These findings provide a potential foundation for precision medicine strategies in HCC, offering novel insights into the tumor-immune microenvironment and its clinical implications.
Authors
- Meiling Guo (ORCID: https://orcid.org/0000-0002-9339-8948)
- Huangshu Lei
- Shuqi Liu (ORCID: https://orcid.org/0000-0002-9606-4871)
- Yiyan Zhai (ORCID: https://orcid.org/0000-0003-0134-2734)
- Jiarui Wu (ORCID: https://orcid.org/0000-0002-1617-6110)
- Xuan Fan
- Jiangying Liu (ORCID: https://orcid.org/0000-0002-6437-4330)
- Peizhi Ye
- Tong Zhao (ORCID: https://orcid.org/0000-0002-4035-196X)
- P. H. Lu
Institutions
- Beijing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Cancer Center (US)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-23
- DOI
- https://doi.org/10.1007/s12672-025-04094-7
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00