Dihydromyricetin ameliorates vascular dementia by promoting angiogenesis via the VEGFR2 pathway: Network pharmacology, molecular docking and experimental validation
To our knowledge, this is the first study to demonstrate that DMY improves cognitive function in VD by enhancing angiogenesis and CBF through VEGFR2 pathway activation. Our findings offer new insights into the therapeutic potential of DMY for VD.
Authors
- Mingxi Li
- Yongchun Wang (ORCID: https://orcid.org/0000-0002-8297-2908)
- Weijie Zhai
- Kan Wang (ORCID: https://orcid.org/0000-0003-0704-8069)
- Guimei Zhang (ORCID: https://orcid.org/0000-0001-7463-5349)
- Li Sun (ORCID: https://orcid.org/0000-0002-0837-7422)
- Shengyu Zhou (ORCID: https://orcid.org/0000-0002-6254-2986)
- Chunxiao Wei
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1016/j.phymed.2025.157593
- Citations
- 1
- Primary Topic
- Medicinal plant effects and applications
- Type
- article
- Field-Weighted Citation Impact
- 2.38