Temporal metabolic reprogramming in DSS-induced colitis identifies purine metabolism and trigonelline as novel therapeutic targets
This study provides a comprehensive temporal map of metabolic reprogramming during colitis progression and identifies purine metabolism and trigonelline as novel therapeutic targets. These findings highlight the translational potential of multi-organ metabolomic approaches in elucidating disease mechanisms and guiding precision treatment strategies for IBD and related inflammatory conditions.
Authors
- Kangjie Song
- Yaming Zhang (ORCID: https://orcid.org/0000-0002-9846-8984)
- Long Zhang (ORCID: https://orcid.org/0000-0002-6811-0439)
- Jianguo Wang (ORCID: https://orcid.org/0000-0002-4908-6840)
- Qi Zhang (ORCID: https://orcid.org/0000-0001-6197-0973)
- Xiaoming Sun
- Fubao Liu (ORCID: https://orcid.org/0000-0003-1700-6890)
Institutions
- Anhui Medical University (CN)
- Zhejiang Provincial People's Hospital (CN)
- Anqing City Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.3389/fphar.2025.1691978
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00