An integrative approach to detecting potential blood-based biomarkers of cognitive frailty
We identified three promising biomarkers-GDF15, myristic acid, and nicotinamide-for cognitive frailty. Notably, low plasma myristic acid levels emerged as the most significant contributor to the prediction model. Further refinement and large-scale validation will be essential to support its future clinical application.
Authors
- Shosuke Satake (ORCID: https://orcid.org/0000-0003-0301-1461)
- Yasumoto Matsui (ORCID: https://orcid.org/0000-0001-7105-0919)
- Tohru Hosoyama (ORCID: https://orcid.org/0000-0002-1825-6923)
- Marie Takemura
- Daichi Shigemizu (ORCID: https://orcid.org/0000-0002-4412-0552)
- Kouichi Ozaki (ORCID: https://orcid.org/0000-0003-0028-1570)
- Risa Mitsumori (ORCID: https://orcid.org/0009-0000-3383-1327)
- Motoki Furutani
- Shumpei Niida (ORCID: https://orcid.org/0000-0002-6192-8035)
- Yukiko Nakano
- Mutsumi Suganuma
Institutions
- Hiroshima University (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
- National Center for Geriatrics and Gerontology (JP)
Publication Details
- Journal
- The journal of nutrition health & aging
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1016/j.jnha.2025.100726
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00