Cardiac Somatostatin-receptor Expression Demonstrated by 68Ga DOTANOC PET/CT in a Child Presenting With Neuroblastoma and Presumed Catecholamine-induced Cardiomyopathy

Hypertension in pediatric neuroblastoma can be challenging to manage due to its multifactorial etiology. We present a 3-year-old girl who presented with cardiogenic shock, echocardiographic evidence of dilated cardiomyopathy, right renal artery stenosis, and elevated catecholamines. Somatostatin receptor (SSTR) PET/CT revealed intense tracer uptake in a right adrenal mass and a low-grade diffuse myocardial uptake, suggestive of inflammatory myocarditis. This unusual finding highlights the potential role of SSTR PET/CT in detecting signs of myocarditis, with myocardial SSTR uptake as a possible biomarker of cardiac inflammation.

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Publication Details

Journal
Clinical Nuclear Medicine
Published
2025-11-07
DOI
https://doi.org/10.1097/rlu.0000000000006196
Primary Topic
Neuroblastoma Research and Treatments
Type
article
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article

Cardiac Somatostatin-receptor Expression Demonstrated by 68Ga DOTANOC PET/CT in a Child Presenting With Neuroblastoma and Presumed Catecholamine-induced Cardiomyopathy

Srinivas Ananth Kumar, Swaminathan Keerthivasagam, Harish Goyal, Sataroopa Mishra et al.
Clinical Nuclear Medicine
Neuroblastoma Research and Treatments
article

Cardiac Somatostatin-receptor Expression Demonstrated by 68Ga DOTANOC PET/CT in a Child Presenting With Neuroblastoma and Presumed Catecholamine-induced Cardiomyopathy

Srinivas Ananth Kumar, Swaminathan Keerthivasagam, Harish Goyal, Sataroopa Mishra, Vishnu Balgi
article en

Abstract

Hypertension in pediatric neuroblastoma can be challenging to manage due to its multifactorial etiology. We present a 3-year-old girl who presented with cardiogenic shock, echocardiographic evidence of dilated cardiomyopathy, right renal artery stenosis, and elevated catecholamines. Somatostatin receptor (SSTR) PET/CT revealed intense tracer uptake in a right adrenal mass and a low-grade diffuse myocardial uptake, suggestive of inflammatory myocarditis. This unusual finding highlights the potential role of SSTR PET/CT in detecting signs of myocarditis, with myocardial SSTR uptake as a possible biomarker of cardiac inflammation.

Clinical Nuclear Medicine
Institute of Cardiology (PL), Jawaharlal Institute of Post Graduate Medical Education and Research (IN)
Openalex Percentile: Top 50%
Neuroblastoma Research and Treatments
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Cardiac Somatostatin-receptor Expression Demonstrated by 68Ga DOTANOC PET/CT in a Child Presenting With Neuroblastoma and Presumed Catecholamine-induced Cardiomyopathy — Srinivas Ananth Kumar, Swaminathan Keerthivasagam, et al. · Clinical Nuclear Medicine (2025) | TGRS Research Map | TGRS