Papillary Thyroid Carcinoma Presenting as Multinodular Goiter With Possible Metastasis: A Case Study

Multinodular goiter (MNG), which may be caused by a variety of risk factors, is typically incidentally found. It is not uncommon for an incidental finding of MNG to lead to a diagnosis of papillary thyroid carcinoma (PTC); however, close monitoring for metastasis is necessary in high-risk patients. Herein, we present the case of a 71-year-old male, seemingly following a normal path of incidental discovery of MNG leading to PTC upon thyroid ultrasound and fine-needle aspiration (FNA) biopsy diagnostic exams. A total thyroidectomy was performed, with pathology confirming an aggressive tumor type (tall cell variant, T4a). Postoperative findings revealed extrathyroidal extension (ETE) with possible lung metastasis. Complications such as these highlight the importance of closely monitoring patients with a higher risk of aggressive thyroid cancer.

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Journal
Cureus
Published
2025-11-23
DOI
https://doi.org/10.7759/cureus.97589
Primary Topic
Thyroid Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Papillary Thyroid Carcinoma Presenting as Multinodular Goiter With Possible Metastasis: A Case Study

Stella Ilyayeva, T. Levitt, Tiffany Tran, Aron Yunatanov et al.
Cureus
Thyroid Cancer Diagnosis and Treatment
article

Papillary Thyroid Carcinoma Presenting as Multinodular Goiter With Possible Metastasis: A Case Study

Stella Ilyayeva, T. Levitt, Tiffany Tran, Aron Yunatanov, Rafael Ilyaev, Jonathan Gulkarov, Andrew Zalot, Avraham Izrailov
article en

Abstract

Multinodular goiter (MNG), which may be caused by a variety of risk factors, is typically incidentally found. It is not uncommon for an incidental finding of MNG to lead to a diagnosis of papillary thyroid carcinoma (PTC); however, close monitoring for metastasis is necessary in high-risk patients. Herein, we present the case of a 71-year-old male, seemingly following a normal path of incidental discovery of MNG leading to PTC upon thyroid ultrasound and fine-needle aspiration (FNA) biopsy diagnostic exams. A total thyroidectomy was performed, with pathology confirming an aggressive tumor type (tall cell variant, T4a). Postoperative findings revealed extrathyroidal extension (ETE) with possible lung metastasis. Complications such as these highlight the importance of closely monitoring patients with a higher risk of aggressive thyroid cancer.

CureusVol. 17(11)
Hofstra University (US), St. John's University (US), Diabetes Australia (AU), St. John's University (TW), New York Institute of Technology (US)
Openalex Percentile: Top 52%
Thyroid Cancer Diagnosis and Treatment
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Papillary Thyroid Carcinoma Presenting as Multinodular Goiter With Possible Metastasis: A Case Study — Stella Ilyayeva, T. Levitt, et al. · Cureus (2025) | TGRS Research Map | TGRS