Cardiovascular Outcomes and Hyperkalemia Risk in Patients With Diabetes, Chronic Kidney Disease and Heart Failure: A Real-World Comparison of Non-steroidal versus Steroidal Mineralocorticoid Receptor Antagonists
In patients with T2DM, CKD, and HF, non-steroidal MRAs were associated with improved safety and cardiovascular outcomes compared with steroidal MRAs. However, the observational study design and, hence, the limitation in data that can be collected warrant cautious interpretation. Prospective randomized head-to-head trials are warranted before adaptation in clinical practice.
Authors
- Abiodun Idowu (ORCID: https://orcid.org/0000-0003-4702-9233)
- Ansar Hassan (ORCID: https://orcid.org/0000-0001-6865-2679)
- Emmanuel Otabor (ORCID: https://orcid.org/0009-0006-7902-6909)
- Michael Hamilton (ORCID: https://orcid.org/0000-0002-5519-4821)
- Ayoyimika O Okunlola
- Justin Lam
- Laith Alomari
- Olayinka Kolawole
Institutions
- Robert Wood Johnson University Hospital (US)
- Saint Peter's University Hospital (US)
- University of Hull (GB)
- Hull University Teaching Hospitals NHS Trust (GB)
- United Lincolnshire Hospitals NHS Trust (GB)
- Jefferson Hospital (US)
Publication Details
- Journal
- Cureus
- Published
- 2025-11-23
- DOI
- https://doi.org/10.7759/cureus.97588
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00