Human induced pluripotent stem cell-derived neurons and coculture conditions regulate the adipogenic differentiation and functionality of human adipose stromal/stem cells
This research provides a novel human cell-based 3D in vitro model to study adipose tissue innervation and neuro-adipose interactions. Here, the novel human cell-based coculture model holds great potential for future mechanistic studies of neuro-adipose regulation.
Authors
- Sini Saarimaa
- Reija Autio (ORCID: https://orcid.org/0000-0002-6519-2715)
- Susanna Miettinen (ORCID: https://orcid.org/0000-0002-0647-9556)
- Susanna Narkilahti (ORCID: https://orcid.org/0000-0002-7602-4418)
- Miia Juntunen (ORCID: https://orcid.org/0000-0001-5282-4376)
- Lotta Isosaari (ORCID: https://orcid.org/0000-0001-9588-4520)
- Marika Kuuskeri
Institutions
- Tampere University (FI)
- Tampere University Hospital (FI)
- Tampere University (FI)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s12964-025-02544-x
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00