Bushen Huatan formula alleviates polycystic ovary syndrome in rats by activating the PI3K/Akt pathway to inhibit GSDMD-mediated pyroptosis and mitochondrial damage
This study shows that BSHT dose-dependently activates the PI3K/Akt pathway, inhibits GSDMD-mediated pyroptosis, and improves mitochondrial dysfunction in PCOS. Its regulation of inflammation, oxidative stress, metabolism, and ovarian function suggests a promising multi-target therapeutic strategy and provides insights for future clinical applications.
Authors
- Mengyue Shen (ORCID: https://orcid.org/0009-0004-4821-2624)
- Qian Xiong (ORCID: https://orcid.org/0000-0002-0547-039X)
- Penglong Yu (ORCID: https://orcid.org/0000-0001-7659-8991)
- H. J. Yang (ORCID: https://orcid.org/0009-0004-8274-9863)
- Jiao Liang
- Qingyan Liu
Institutions
- Chengdu Medical College (CN)
- People’s Hospital of Rizhao (CN)
- Chongqing Three Gorges University (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s13048-025-01887-w
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81