Fusobacterium nucleatum-reprogrammed adipocytes promote tumor cisplatin resistance through the CCL2-CCR2 axis in the necrotic metastatic neck nodes of head and neck carcinoma
This study is the first to elucidate the crucial involvement of F. nucleatum in shaping cancer-associated adipocytes within the HNSCC microenvironment. F. nucleatum-reprogrammed adipocytes enhance cisplatin resistance via the CCL2-CCR2 axis, offering new therapeutic avenues to overcome chemotherapy resistance in necrotic neck lymph nodes.
Authors
- Yi Zhu (ORCID: https://orcid.org/0000-0002-2222-0106)
- Feiran Li (ORCID: https://orcid.org/0000-0002-0407-6331)
- Hui‐Ching Lau (ORCID: https://orcid.org/0000-0002-6944-2507)
- Hongli Gong (ORCID: https://orcid.org/0000-0002-7257-229X)
- Chi‐Yao Hsueh (ORCID: https://orcid.org/0000-0002-9679-7098)
- Huiying Huang (ORCID: https://orcid.org/0000-0002-5587-3576)
- Xiaohui Yuan (ORCID: https://orcid.org/0000-0001-5516-5919)
- Ming Zhang (ORCID: https://orcid.org/0000-0003-2909-8446)
Institutions
- Eye & ENT Hospital of Fudan University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-11-23
- DOI
- https://doi.org/10.1186/s12964-025-02550-z
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00