Interleukin-18 binding protein protects against metabolic steatohepatitis
IL-18BP has a role in limiting the progression of MASH, notably by reducing inflammation and fibrosis. Downstream IL-18 over-signaling, IFN-γ, mediates inflammation, but not fibrosis. Increasing IL-18BP levels represents a novel therapeutic perspective for patients affected by MASH.
Authors
- Franck Bontems (ORCID: https://orcid.org/0000-0002-1220-5842)
- Anne‐Claude Gavin (ORCID: https://orcid.org/0000-0003-4917-2340)
- Sabrina Pagano (ORCID: https://orcid.org/0000-0001-7075-1182)
- Christelle Veyrat‐Durebex (ORCID: https://orcid.org/0000-0001-5301-6493)
- Cem Gabay (ORCID: https://orcid.org/0000-0001-6853-3063)
- Emmanuel Somm (ORCID: https://orcid.org/0000-0002-0649-3542)
- Karim Gariani (ORCID: https://orcid.org/0000-0001-8089-4785)
- Florian Visentin (ORCID: https://orcid.org/0009-0007-2030-1707)
- Karina Lindner (ORCID: https://orcid.org/0000-0002-2422-2789)
- Yunju Jo (ORCID: https://orcid.org/0000-0002-6305-3324)
- Baeki E. Kang (ORCID: https://orcid.org/0000-0002-7747-404X)
- François R. Jornayvaz (ORCID: https://orcid.org/0000-0001-9425-3137)
- Sébastien Fauteux‐Daniel (ORCID: https://orcid.org/0000-0001-7863-5717)
- Irmgard Förster (ORCID: https://orcid.org/0000-0002-7644-5642)
- Nicolas Vuilleumier (ORCID: https://orcid.org/0000-0002-1122-438X)
- Elodie Perroud
- Dongryeol Ryu (ORCID: https://orcid.org/0000-0001-5905-6760)
- Frédérique Ino (ORCID: https://orcid.org/0009-0008-3077-9752)
Institutions
- University of Geneva (CH)
- University of Bonn (DE)
- Gwangju Institute of Science and Technology (KR)
- University Hospital of Geneva (CH)
- Geneva College (US)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1097/hc9.0000000000000840
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00