Association of neighborhood disadvantage with Alzheimer's disease pathology and the stability of blood-based biomarker performance
The diagnostic performance of plasma AD biomarkers is robust and is not compromised by neighborhood-level disadvantage. These findings support the generalizability and equitable clinical utility of biomarkers like p-tau217/Aβ42 for AD diagnosis across diverse socioeconomic settings.
Authors
- Marta Milà‐Alomà (ORCID: https://orcid.org/0000-0002-5687-4597)
- Alison Myoraku
- Laura A. Wang (ORCID: https://orcid.org/0000-0001-6488-2573)
- Duygu Tosun (ORCID: https://orcid.org/0000-0001-5174-3910)
- Pamela Thropp (ORCID: https://orcid.org/0009-0006-5371-8667)
- P. Murali Doraiswamy (ORCID: https://orcid.org/0000-0003-0697-3893)
- Isabella Hausle
Institutions
- Duke University (US)
- University of California, San Francisco (US)
- Cognitive Research (United States) (US)
- Northern California Institute for Research and Education (US)
Publication Details
- Journal
- The Journal of Prevention of Alzheimer s Disease
- Published
- 2025-11-23
- DOI
- https://doi.org/10.1016/j.tjpad.2025.100445
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00