Optimized methods for efficient application of immunogold electron microscopy to amyloid fibrils typing
This optimized IEM technique enhances the accuracy and efficiency of amyloid typing, especially in samples with trace amyloid deposit. It offers significant advantages over traditional epoxy embedding with toluidine blue staining, supporting timely clinical diagnosis and therapeutic decision-making.
Authors
- Tatiana Prokaeva (ORCID: https://orcid.org/0000-0002-0790-602X)
- Vaishali Sanchorawala (ORCID: https://orcid.org/0000-0002-6307-2445)
- Eric Burks (ORCID: https://orcid.org/0000-0002-3122-2875)
- Zahra Sheikh (ORCID: https://orcid.org/0000-0002-3903-9039)
- Joel Henderson (ORCID: https://orcid.org/0000-0002-9178-1708)
- Chris Andry (ORCID: https://orcid.org/0000-0003-3291-9604)
- Hui Chen (ORCID: https://orcid.org/0000-0001-5704-5486)
- Lu W (ORCID: https://orcid.org/0000-0002-6570-3044)
- Yan Zhou (ORCID: https://orcid.org/0000-0003-0757-4341)
Institutions
- Boston Medical Center (US)
- Amyloidosis Foundation (US)
Publication Details
- Journal
- Amyloid
- Published
- 2025-11-23
- DOI
- https://doi.org/10.1080/13506129.2025.2589892
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00