Association between glucosamine use and albuminuria in the UK: a cohort and Mendelian randomisation study
We found that detectable albuminuria was common in UK Biobank participants and we are the first to show that use of glucosamine supplements was associated with lower levels. Though this fits with a plausible biological role of the vascular endothelium in a potential protective effect of glucosamine use on many health outcomes, whether this relationship is causal or confounded remains unclear. We further discuss the inherent difficulties in using genetic instruments to proxy supplement use in MR analyses and highlight the need for a genome-wide association study of measured circulating glucosamine levels.
Authors
- Andrei Constantinescu (ORCID: https://orcid.org/0000-0001-5030-0907)
- Matthew Butler (ORCID: https://orcid.org/0000-0002-9814-8008)
- Simon C. Satchell (ORCID: https://orcid.org/0000-0001-5276-4537)
- Emma E. Vincent (ORCID: https://orcid.org/0000-0002-8917-7384)
- Emma Hazelwood (ORCID: https://orcid.org/0000-0002-4888-6037)
- Samantha Hayward (ORCID: https://orcid.org/0000-0002-3234-7549)
Institutions
- North Bristol NHS Trust (GB)
- University of Bristol (GB)
Publication Details
- Journal
- BMJ Open
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1136/bmjopen-2024-096344
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- World Cancer Research Fund International
- Cancer Research UK
- Diabetes UK
- University of Bristol
- Medical Research Council
- World Cancer Research Fund