Procaine alleviates microglial pyroptosis by inhibiting O-GlcNAcylation of NOD-like receptor family, pyrin domain-containing 3 through the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway
Procaine alleviated LPS-induced microglial pyroptosis by inhibiting OGT-mediated O-GlcNAcylation of NLRP3 through inactivating the JAK2/STAT3 signaling pathway. Our research provides a potential therapeutic strategy for neuropathic pain.
Authors
- Ruichen Zang
- QingDong Wang (ORCID: https://orcid.org/0009-0000-3158-8458)
- Kai Zhang (ORCID: https://orcid.org/0000-0003-4237-3115)
Institutions
- Chinese PLA General Hospital (CN)
- First Affiliated Hospital of Jiamusi University (CN)
Publication Details
- Journal
- Neuroreport
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1097/wnr.0000000000002226
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81