USP20 competitively binds to STUB1 to enhance CTSL expression and promote epithelial‐mesenchymal transition in head and neck squamous cell carcinoma
USP20 deubiquitinates and stabilizes CTSL. STUB1 promotes CTSL ubiquitination and degradation. USP20 competitively binds to CTSL in competition with STUB1. Targeting USP20 sensitizes cancer cells to cisplatin or paclitaxel.
Authors
- Baihui Zhang (ORCID: https://orcid.org/0000-0002-5934-2924)
- X. Z. Cui (ORCID: https://orcid.org/0000-0001-8242-8964)
- Susheng Miao (ORCID: https://orcid.org/0000-0002-7701-9362)
- Kaibin Song (ORCID: https://orcid.org/0000-0003-2681-9287)
- Lunhua Guo (ORCID: https://orcid.org/0009-0000-6062-3937)
- Junze Xiao (ORCID: https://orcid.org/0009-0004-5277-4048)
- Ji Sun (ORCID: https://orcid.org/0000-0001-9260-2292)
Institutions
- Central South University (CN)
- Harbin Medical University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Education Department of Heilongjiang Province (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/ctm2.70520
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00