Downregulation of aquaporin 3 promotes hyperosmolarity-induced apoptosis of nucleus pulposus cells through PI3K/Akt/mTOR pathway suppression
Our findings indicate that AQP3 deficiency under hyperosmotic conditions contributes to NPC apoptosis by suppressing the PI3K/AKT/mTOR signaling pathway, potentially establishing a pathological cycle of disc degeneration. These results highlight AQP3 as a potential therapeutic target for IVDD.
Authors
- Yuan Sang
- Wenbin Xu (ORCID: https://orcid.org/0000-0003-4338-0368)
- Gang Hou (ORCID: https://orcid.org/0000-0003-3438-1764)
- Chang Liu (ORCID: https://orcid.org/0000-0001-6392-3871)
- Ping Li (ORCID: https://orcid.org/0000-0002-4926-3835)
- Ting Zhang (ORCID: https://orcid.org/0000-0001-6133-1629)
- Jiajun Wu (ORCID: https://orcid.org/0000-0002-4176-343X)
- Kaihua Liu (ORCID: https://orcid.org/0000-0002-7666-1273)
- Yichun Xu (ORCID: https://orcid.org/0000-0002-2243-3371)
- Jianying Zhang (ORCID: https://orcid.org/0000-0002-1460-2817)
- Huiqing Zhao
Institutions
- Sun Yat-sen University (CN)
- University of Pittsburgh (US)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-11-04
- DOI
- https://doi.org/10.3389/fgene.2025.1665899
- Citations
- 1
- Primary Topic
- Ion Transport and Channel Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Sun Yat-sen University
- Basic and Applied Basic Research Foundation of Guangdong Province