Loss of GPR146 decreases plasma levels of HDL cholesterol via post-translational up-regulation of SR-B1 protein levels
This study suggests that loss of GPR146 reduces HDL cholesterol via post-translational up-regulation of hepatic SR-B1 via an intracellular pathway that remains to be resolved. These findings imply that GPR146 inhibition to treat hypercholesterolaemia may not only lower plasma levels of LDL cholesterol but also HDL cholesterol.
Authors
- Nicolette Huijkman
- Jan Albert Kuivenhoven (ORCID: https://orcid.org/0000-0002-9346-2719)
- Arnold von Eckardstein (ORCID: https://orcid.org/0000-0002-1666-2266)
- Laurent O. Martinez (ORCID: https://orcid.org/0000-0002-0985-3152)
- Umesh Tharehalli (ORCID: https://orcid.org/0000-0002-4907-5017)
- Bart van de Sluis (ORCID: https://orcid.org/0000-0003-3039-4365)
- Patrick C.N. Rensen (ORCID: https://orcid.org/0000-0002-8455-4988)
- Federico Oldoni (ORCID: https://orcid.org/0000-0001-5900-1399)
- Antoine Rimbert (ORCID: https://orcid.org/0000-0002-2971-4926)
- Lisanne L. Blauw (ORCID: https://orcid.org/0000-0002-6997-0895)
- Niels Kloosterhuis (ORCID: https://orcid.org/0009-0000-5500-3282)
- Justina C. Wolters (ORCID: https://orcid.org/0000-0003-0066-3720)
- Natalia Loaiza
- Jérôme Robert (ORCID: https://orcid.org/0000-0002-2847-9362)
- Boyan Zhang (ORCID: https://orcid.org/0000-0002-6653-0085)
- Marieke Smit
Institutions
- Centre National de la Recherche Scientifique (FR)
- University Medical Center Groningen (NL)
- Université Toulouse III - Paul Sabatier (FR)
- Inserm (FR)
- University of Groningen (NL)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- University of Zurich (CH)
- Leiden University Medical Center (NL)
- University Hospital of Zurich (CH)
- Institut du Thorax (FR)
- Institut des Maladies Métaboliques et Cardiovasculaires (FR)
- Nantes Université (FR)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1093/cvr/cvaf254
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00