Profiles of blood–brain barrier and neurodegeneration markers in cerebrospinal fluid of patients with cerebral amyloid angiopathy
New diagnostic criteria allow for the diagnosis of CAA without hemorrhagic markers.CAA hemorrhagic markers are associated with lower Aβ42 and Aβ40 in CSF.CAA hemorrhagic markers are associated with higher blood-brain barrier permeability.Higher imaging burden of CAA is associated with higher total tau protein in CSF.
Authors
- Ana Sofia Costa (ORCID: https://orcid.org/0000-0002-1999-6616)
- Arno Reich (ORCID: https://orcid.org/0000-0002-9439-7963)
- Jörg B. Schulz (ORCID: https://orcid.org/0000-0002-8903-0593)
- Kathrin Reetz (ORCID: https://orcid.org/0000-0002-9730-9228)
- João Pinho (ORCID: https://orcid.org/0000-0002-3977-7146)
- Omid Nikoubashman (ORCID: https://orcid.org/0000-0002-2055-4217)
Institutions
- Evangelisches Krankenhaus Bielefeld (DE)
- Universitätsklinikum Aachen (DE)
- Jülich Aachen Research Alliance (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/dad2.70221
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- RWTH Aachen University