Characteristics of <i>KRAS</i> WT pancreatic adenocarcinomas: results of a large French multicentric cohort
<i>KRAS</i> WT tumours are enriched with molecular abnormalities of therapeutic interest. These include oncogene driver alterations (gene fusions and mutations) and mutations in genes of the HR pathway. Targeted therapy strategies for PDAC rely on molecular testing beyond <i>RAS</i>, but further research is needed to identify new therapeutic approaches that improve outcomes in PDAC.
Authors
- Alexandre Harlé (ORCID: https://orcid.org/0000-0001-9548-6522)
- Vinciane Rebours (ORCID: https://orcid.org/0000-0002-0000-4525)
- Laëtitia Dahan (ORCID: https://orcid.org/0000-0001-5267-6190)
- Jim J Biagi
- Simon Garinet (ORCID: https://orcid.org/0000-0002-2182-8793)
- Thierry Conroy (ORCID: https://orcid.org/0000-0001-7548-284X)
- Julien Taı̈eb (ORCID: https://orcid.org/0000-0002-9955-4753)
- Rémy Nicolle (ORCID: https://orcid.org/0000-0001-8084-1173)
- Hélène Blons (ORCID: https://orcid.org/0000-0002-0572-8426)
- Jérôme Cros (ORCID: https://orcid.org/0000-0002-4935-3865)
- Jean‐Baptiste Bachet (ORCID: https://orcid.org/0000-0003-4337-286X)
- Delphine Le Corre
- Noémie Trystram (ORCID: https://orcid.org/0000-0003-2630-0899)
- Pierre Laurent‐Puig (ORCID: https://orcid.org/0000-0001-8475-5459)
- Shengguang Zhao (ORCID: https://orcid.org/0000-0002-4197-8887)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Shanghai Jiao Tong University (CN)
- Queen's University (CA)
- Université Paris Cité (FR)
- Hôpital Beaujon (FR)
- Ruijin Hospital (CN)
- Sorbonne Université (FR)
- Centre de Recherche des Cordeliers (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Institut de Cancérologie de Lorraine (FR)
- Hôpital Européen (FR)
- Pitié-Salpêtrière Hospital (FR)
- Centre de Recherche sur l'Inflammation (FR)
- Hôpital de la Timone (FR)
- Interdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes – Région Est (FR)
- Université de Lorraine (FR)
Publication Details
- Journal
- Therapeutic Advances in Medical Oncology
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1177/17588359251339939
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 0.00