Aberrant DNA methylation within circadian entrainment and clock genes two years after pediatric critical illness is associated with impaired physical and neurocognitive development
Former PICU patients exhibited altered DNA methylation in circadian entrainment and clock genes compared to healthy children, and this was associated with impaired growth, neurocognition and behavioral problems at two-year follow-up. Disruptions in circadian entrainment and clock gene methylation may contribute to the adverse long-term health consequences that children experience after critical illness.
Authors
- Sascha C. A. T. Verbruggen (ORCID: https://orcid.org/0000-0003-4866-9865)
- Grégoire Coppens (ORCID: https://orcid.org/0000-0001-7637-3549)
- Ilse Vanhorebeek (ORCID: https://orcid.org/0000-0002-5261-5192)
- Pieter Wouters
- Matthijs de Hoog (ORCID: https://orcid.org/0000-0002-1259-581X)
- Arnout B.G. Cramer (ORCID: https://orcid.org/0000-0001-6930-4350)
- Inês Chaves (ORCID: https://orcid.org/0000-0001-6494-0008)
- Fabián Güiza (ORCID: https://orcid.org/0000-0001-7026-0957)
- Karolijn Dulfer (ORCID: https://orcid.org/0000-0002-0158-6539)
- Koen F. M. Joosten (ORCID: https://orcid.org/0000-0002-0504-2475)
- Greet Van den Berghe
Institutions
- Erasmus MC - Sophia Children’s Hospital (NL)
- Erasmus MC Cancer Institute (NL)
- KU Leuven (BE)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-11-23
- DOI
- https://doi.org/10.1186/s13148-025-02027-3
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Society for Clinical Nutrition and Metabolism
- Vlaamse regering