Schisandrin C alleviates depressive-like behaviors by modulating the AKT/CREB/BDNF pathway, the serotonin pathway of tryptophan metabolism, and the gut microbiota composition
SCC improves depressive-like behaviors by modulating the microbiota‒gut‒brain axis. These findings underscore the potential of SCC as an effective therapeutic agent for depression.
Authors
- Keunwan Park (ORCID: https://orcid.org/0000-0002-8783-9495)
- Kyung‐Joon Cha (ORCID: https://orcid.org/0000-0003-2261-0785)
- Emmanuel Hitayezu (ORCID: https://orcid.org/0000-0002-3822-3619)
- Siqi Zhang (ORCID: https://orcid.org/0009-0002-8142-8078)
- SoHyun Lee (ORCID: https://orcid.org/0000-0001-9992-6038)
- Hyeon‐Seong Lee
- Uyen Tran Tu Nguyen (ORCID: https://orcid.org/0000-0002-7973-7528)
- Kyungsu Kang (ORCID: https://orcid.org/0000-0003-3846-7936)
- Hak Cheol Kwon (ORCID: https://orcid.org/0000-0002-4071-2331)
- Joonki Kim (ORCID: https://orcid.org/0000-0002-5583-1085)
- Suk Woo Kang (ORCID: https://orcid.org/0000-0002-5678-6394)
- Jaeyoung Kwon (ORCID: https://orcid.org/0000-0002-8706-2305)
- Sae Hun Kim (ORCID: https://orcid.org/0000-0002-0990-2268)
- Son Hung Tran (ORCID: https://orcid.org/0000-0002-3276-2611)
Institutions
- Gangneung–Wonju National University (KR)
- Gangwon Provincial University (KR)
- Korea University (KR)
- Institute of Natural Science (KP)
- Korea Institute of Science and Technology (KR)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-11-23
- DOI
- https://doi.org/10.1016/j.phymed.2025.157581
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00