A Collection of Patient-Derived Intestinal Organoid Lines Reveals Epithelial Phenotypes Associated with Genetic Drivers of Pediatric Inflammatory Bowel Disease
These findings underscore the potential of IEOs as a valuable model for studying IBD and offer key insights that could guide the development of targeted therapies for both monogenic and non-monogenic forms of IBD.
Authors
- Johan H. van Es (ORCID: https://orcid.org/0000-0002-1338-7078)
- Daniel Kotlarz (ORCID: https://orcid.org/0000-0002-4576-6769)
- Scott B. Snapper (ORCID: https://orcid.org/0000-0003-0267-4247)
- Ewart Kuijk (ORCID: https://orcid.org/0000-0002-1385-6516)
- Hans Clevers (ORCID: https://orcid.org/0000-0002-3077-5582)
- Carmen Argmann (ORCID: https://orcid.org/0000-0002-1110-8012)
- Edward E. S. Nieuwenhuis (ORCID: https://orcid.org/0000-0001-8094-1211)
- Phillip Comella (ORCID: https://orcid.org/0000-0002-0260-3847)
- Eric E. Schadt (ORCID: https://orcid.org/0000-0002-7892-8808)
- Maaike Hillegonda de Vries (ORCID: https://orcid.org/0009-0008-1341-230X)
- Michal Mokrý (ORCID: https://orcid.org/0000-0002-5298-4852)
- Lauren V. Collen (ORCID: https://orcid.org/0000-0002-7769-8123)
- Mia Sveen
- Christoph A. Klein (ORCID: https://orcid.org/0000-0003-0956-0445)
- Zahra Shojaei Jeshvaghani (ORCID: https://orcid.org/0000-0003-2383-0050)
Institutions
- Boston Children's Hospital (US)
- Royal Netherlands Academy of Arts and Sciences (NL)
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- LMU Klinikum (DE)
- Princess Máxima Center (NL)
- Wilhelmina Children's Hospital (NL)
- Ludwig-Maximilians-Universität München (DE)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1093/ibd/izaf296
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00