Machine learning model for HBsAg seroclearance after 48-week pegylated interferon therapy in inactive HBsAg carriers: a retrospective study
The RF-based model accurately predicts HBsAg clearance in IHC patients undergoing Peg-IFN therapy and offers a promising tool for early identification of candidates for individualized treatment strategies.
Authors
- Bingliang Lin (ORCID: https://orcid.org/0000-0003-4069-6287)
- Sujun Zheng
- Ping Wu (ORCID: https://orcid.org/0000-0003-0423-2178)
- Yueyong Zhu (ORCID: https://orcid.org/0000-0002-0746-4911)
- Junliang Fu (ORCID: https://orcid.org/0009-0001-8318-6888)
- Jianxia Dong
- Haitian Yu
- Qingfa Ruan
- Jing Zhao (ORCID: https://orcid.org/0000-0001-7346-9959)
- Haidong Zhao (ORCID: https://orcid.org/0000-0003-0985-0004)
- Yao Xie (ORCID: https://orcid.org/0000-0002-3175-0213)
- Yongfang Jiang (ORCID: https://orcid.org/0000-0001-7415-4289)
- Xinyue Chen (ORCID: https://orcid.org/0000-0003-3212-2398)
- Haifang Cao
- Shan Ren (ORCID: https://orcid.org/0000-0001-9668-8249)
- Xiaorong Mao (ORCID: https://orcid.org/0000-0002-6072-679X)
- Xiulan Xue
- Zhiliang Gao
Institutions
- Fujian Medical University (CN)
- Union Hospital (HK)
- Central South University (CN)
- Sun Yat-sen University (CN)
- Capital Medical University (CN)
- Chinese PLA General Hospital (CN)
- First Affiliated Hospital of Xiamen University (CN)
- The Fourth People's Hospital (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Beijing YouAn Hospital (CN)
- Beijing Ditan Hospital (CN)
- Qinghai Provincial Peoples Hospital (CN)
- Xiamen Chang Gung Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-11-23
- DOI
- https://doi.org/10.1186/s12985-025-03012-1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00