Patient-derived organoids and neurospheres recapitulate salient features of primary tumor heterogeneity
Our data confirms that both PDN and PDO patient-derived models recapitulate patient intra-tumoral heterogeneity providing a platform for tumor cell state refined therapeutic studies.
Authors
- Keith Lloyd Ligon (ORCID: https://orcid.org/0000-0002-7733-600X)
- Oliver M. Sieber (ORCID: https://orcid.org/0000-0001-9480-0786)
- Daniel V. Brown (ORCID: https://orcid.org/0000-0002-3594-5851)
- Jeanine Pignatelli (ORCID: https://orcid.org/0009-0007-3680-9724)
- Jessica Hart (ORCID: https://orcid.org/0009-0000-1634-8800)
- James Richard Whittle (ORCID: https://orcid.org/0000-0002-4740-2037)
- Katharine J. Drummond (ORCID: https://orcid.org/0000-0002-8152-2120)
- Seth Malinowski (ORCID: https://orcid.org/0000-0001-6468-3451)
- Sarah A. Best (ORCID: https://orcid.org/0000-0002-4232-9432)
- Zachery Moore (ORCID: https://orcid.org/0000-0002-0898-0483)
- Claire Storey (ORCID: https://orcid.org/0000-0002-5428-9909)
- Lachlan Harris (ORCID: https://orcid.org/0000-0002-7820-0921)
- Saskia Freytag (ORCID: https://orcid.org/0000-0002-2185-7068)
- Adam Valkovic (ORCID: https://orcid.org/0000-0002-2086-8224)
- Shannon J. Oliver
- A. Fakhri
- Montana Spiteri
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- The Royal Melbourne Hospital (AU)
- Queensland University of Technology (AU)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
- QIMR Berghofer Medical Research Institute (AU)
- Peter MacCallum Cancer Centre (AU)
- Dana-Farber Cancer Institute (US)
- Boston Children's Museum (US)
- Monash University (AU)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1093/noajnl/vdaf247
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00