An asymptotically exact multiple testing procedure under dependence

We propose a simple single-step multiple testing procedure that asymptotically controls the family-wise error rate (FWER) at the desired level exactly under the equicorrelated multivariate Gaussian setup. The method is shown to be asymptotically exact using an explicit plug-in estimator for the equicorrelation, and does not require stepwise adjustments. We establish its theoretical properties, including the convergence to the desired error level (along with an estimate of the rate of convergence), and demonstrate its effectiveness through simulation results. We also spell out related extensions to unknown equicorrelation, block-correlated structures and generalized FWER control.

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Publication Details

Journal
Statistics & Probability Letters
Published
2025-11-22
DOI
https://doi.org/10.1016/j.spl.2025.110609
Primary Topic
Statistical Methods in Clinical Trials
Type
article
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article

An asymptotically exact multiple testing procedure under dependence

Sunil Datta, Monitirtha Dey
Statistics & Probability Letters
Statistical Methods in Clinical Trials
article

An asymptotically exact multiple testing procedure under dependence

Sunil Datta, Monitirtha Dey
article en

Abstract

We propose a simple single-step multiple testing procedure that asymptotically controls the family-wise error rate (FWER) at the desired level exactly under the equicorrelated multivariate Gaussian setup. The method is shown to be asymptotically exact using an explicit plug-in estimator for the equicorrelation, and does not require stepwise adjustments. We establish its theoretical properties, including the convergence to the desired error level (along with an estimate of the rate of convergence), and demonstrate its effectiveness through simulation results. We also spell out related extensions to unknown equicorrelation, block-correlated structures and generalized FWER control.

Statistics & Probability LettersVol. 230
University of Bremen (DE), Indian Statistical Institute (IN)
Openalex Percentile: Top 67%
Statistical Methods in Clinical Trials
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