Cognitive outcomes following psilocybin-assisted therapy in treatment-resistant depression: A post-hoc analysis of a randomized, waitlist-controlled trial
PAP was associated with modest, short-term improvements in performance on measures of processing speed and executive function among individuals with TRD. While these changes appeared independent of mood, they did not consistently exceed expected practice effects. These findings highlight the need for adequately powered, controlled trials to clarify whether observed cognitive changes reflect genuine procognitive effects of psilocybin or are attributable to non-specific influences such as test familiarity or concurrent mood improvements.
Authors
- Rodrigo B. Mansur (ORCID: https://orcid.org/0000-0002-3968-3297)
- Jennifer S. Rabin (ORCID: https://orcid.org/0000-0003-4754-2221)
- Shakila Meshkat (ORCID: https://orcid.org/0000-0002-7010-1785)
- Danica E. Johnson (ORCID: https://orcid.org/0000-0003-2000-7691)
- Noah Chisamore (ORCID: https://orcid.org/0000-0003-3325-5854)
- Zoe Doyle (ORCID: https://orcid.org/0000-0002-0140-8994)
- Joshua D. Rosenblat (ORCID: https://orcid.org/0000-0002-4773-2191)
- Krista L. Lanctôt (ORCID: https://orcid.org/0000-0001-7024-6637)
- Jordan Bawks
- Orly Lipsitz (ORCID: https://orcid.org/0000-0001-9110-7951)
- Jeremy Riva-Cambrin
- Ryan M. Brudner (ORCID: https://orcid.org/0009-0004-8381-7434)
- Erica Kaczmarek
- Roger S McIntyre
Institutions
- Sunnybrook Health Science Centre (CA)
- University of Toronto (CA)
- Canadian Transplant Association (CA)
- St. Joseph’s Healthcare Hamilton (CA)
Publication Details
- Journal
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1016/j.pnpbp.2025.111565
- Primary Topic
- Psychedelics and Drug Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00