Unveiling the role of integrated stress response in pterygium: EGLN3, HSPA8, and NDRG1 as novel biomarkers and therapeutic targets
EGLN3, HSPA8, and NDRG1 were identified as biomarkers associated with ISR in pterygium. The regulatory networks composed of differed expressions of ISR-related genes, miRNA-mRNA-TF regulatory axes, and immune response played crucial roles in the development of pterygium.
Authors
- Jiayu Gu (ORCID: https://orcid.org/0000-0002-3669-1726)
- Jingyi Cheng (ORCID: https://orcid.org/0000-0003-4932-5589)
- Yidan Fan
- Jianjiang Xu
- Jun Xiang (ORCID: https://orcid.org/0009-0003-8184-9822)
- Jiawen Wu (ORCID: https://orcid.org/0000-0002-9743-8193)
- Ning Lyu (ORCID: https://orcid.org/0009-0009-3458-0705)
- Zhaoyuan Lyu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shanghai Eye Disease Prevention & Treatment Center (CN)
- Eye & ENT Hospital of Fudan University (CN)
- Akita University of Art (JP)
Publication Details
- Journal
- Genomics
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.ygeno.2025.111156
- Citations
- 1
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.36