Trimethylamine-N-oxide disrupts spermatogenesis by inducing mitochondrial oxidative stress injury through Hippo signaling
Our findings demonstrate that TMAO activates Hippo signaling to induce mitochondrial dysfunction and suppress testosterone synthesis, thereby impairing spermatogenesis. These results highlight TMAO biosynthesis and its downstream signaling as potential therapeutic targets for improving male fertility.
Authors
- Houhua Lai
- Xiangming Mao (ORCID: https://orcid.org/0000-0002-7690-0924)
- Lepeng Zhou
- Zhongjie Chen (ORCID: https://orcid.org/0000-0002-1338-4387)
- Cancan Qi (ORCID: https://orcid.org/0000-0003-3825-5802)
- Hongwei Zhou (ORCID: https://orcid.org/0000-0002-9478-4023)
- Yan He (ORCID: https://orcid.org/0009-0003-2947-2642)
- Shuo Wang (ORCID: https://orcid.org/0000-0002-5151-6176)
- Tao Jing (ORCID: https://orcid.org/0000-0003-1936-4392)
- Genshan Ma (ORCID: https://orcid.org/0000-0003-2566-9416)
- Guangyan Wu (ORCID: https://orcid.org/0000-0002-4468-9511)
- Shilong Cheng
Institutions
- Jinan University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- General Hospital of Guangzhou Military Command (CN)
- Second Hospital of Shandong University (CN)
- Zhujiang Hospital (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Free Radical Biology and Medicine
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1016/j.freeradbiomed.2025.11.052
- Citations
- 3
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 3.45