Exploring the role of β2-microglobulin in the relationship between physical activity and DNAm-predicted PhenoAge: Evidence from a population-based and mice single-cell RNA-sequencing study
This study provides evidence that β2M mediates the beneficial effects of PA on biological aging. PA promotes healthy aging through molecular and cellular mechanisms, particularly benefiting individuals with higher baseline inflammation or metabolic dysfunction. These insights advance our understanding of the interplay between PA, β2M, and aging, offering directions for interventions to promote longevity and healthspan.
Authors
- Yang Zhang (ORCID: https://orcid.org/0000-0002-3617-2029)
- Zizhen Yao (ORCID: https://orcid.org/0000-0002-9361-5607)
- Jingtong Wang
- Yanwei You (ORCID: https://orcid.org/0000-0001-8367-4980)
- Yuquan Chen (ORCID: https://orcid.org/0000-0001-5792-6566)
- Alimjan Ablitip (ORCID: https://orcid.org/0000-0003-3349-3828)
- Yongjie Lao
- Kailin Xu (ORCID: https://orcid.org/0000-0002-6931-9074)
- Xindong Ma (ORCID: https://orcid.org/0000-0003-0614-2176)
- Jinwei Li (ORCID: https://orcid.org/0000-0002-4599-995X)
- Qiyu Liu (ORCID: https://orcid.org/0000-0002-6860-5028)
Institutions
- Centre for Addiction and Mental Health (CA)
- Sichuan University (CN)
- Kunming Medical University (CN)
- West China Hospital of Sichuan University (CN)
- Monash Health (AU)
- Hebrew SeniorLife (US)
- Monash University (AU)
- Tsinghua University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.jare.2025.11.047
- Citations
- 4
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 3.81