A novel sono-activatable nanoreactor induces precision intratumoral juglone generation and caspase 3/GSDME-mediated pyroptosis for treatment of bladder cancer
As a novel sonosensitizer and pyroptosis inducer, DHN@Pt/PtMBCPsNSs achieve a precise synergistic effect of chemotherapy and sonodynamic therapy within cells, while minimizing adverse effects on normal cells and overcoming the limitations associated with natural chemotherapeutic agents. This approach may advance clinical translation of natural anticancer agents.
Authors
- Zhilong Dong (ORCID: https://orcid.org/0000-0002-4919-8164)
- Baodui Wang (ORCID: https://orcid.org/0000-0003-1600-6557)
- Junqiang Tian (ORCID: https://orcid.org/0000-0002-4529-4650)
- Ying-Ru Wang
- Liang Cheng (ORCID: https://orcid.org/0000-0002-6665-6710)
- Enguang Yang (ORCID: https://orcid.org/0000-0002-9028-8065)
- Yibo Shi
- Guangrui Fan (ORCID: https://orcid.org/0000-0002-0865-8080)
- Yuhan Wang (ORCID: https://orcid.org/0009-0004-6281-0022)
- Zhiping Wang (ORCID: https://orcid.org/0000-0002-2367-0491)
- Xinyu Zhang (ORCID: https://orcid.org/0000-0001-8154-9334)
- Yuanfeng Zhang (ORCID: https://orcid.org/0000-0002-5833-3460)
- Yonghai Zhang (ORCID: https://orcid.org/0009-0004-6121-427X)
- Zhi‐Wen Zhao (ORCID: https://orcid.org/0000-0002-7489-249X)
- Hanzhang Wang (ORCID: https://orcid.org/0009-0006-0650-173X)
Institutions
- University of Electronic Science and Technology of China (CN)
- Lanzhou University of Technology (CN)
- Brown University (US)
- Lanzhou University Second Hospital (CN)
- Shantou Central Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1186/s12951-025-03855-4
- Citations
- 1
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.67