Çoklu İlaca Dirençli Bakteri İzolatlarına Karşı Laetiporus sulphureus Ekstraktlarının Antibakteriyel Aktivitesi

Ethanol extracts from Laetiporus sulphureus (Bull.) Murrill (Polyporaceae) were tested for their antibacterial activity against multidrug-resistant bacterial isolates using agar well diffusion and dilution procedures. According to the findings, L. sulphureus's antibacterial activity differed depending on the extract concentration. While no activity was observed at other dosages, the ethanolic extract demonstrated inhibitory zones ranging from 10.2 to 17.4 mm at 200 mg/mL; 8.2 to 12.6 mm at 100 mg/mL; and 9.2 to 9.8 mm at 50 mg/mL. Klebsiella pneumoniae (10.2 mm at 200 mg/mL) was the least susceptible to the extract, while Bacillus subtilis (17.4 mm at 200 mg/mL) was the most sensitive. The extract’s minimum inhibitory concentration (MIC) against Staphylococcus aureus, B. subtilis, and K. pneumoniae ranged between 25 mg/mL and 200 mg/mL. For B. subtilis, S. aureus, and Pseudomonas aeruginosa, the minimum bactericidal concentration (MBC) of the extract was recorded at 50 mg/mL and 200 mg/mL, respectively; however, no MBC was found for K. pneumoniae. S. aureus exhibited the highest level of resistance (70%), while P. aeruginosa demonstrated the lowest level of resistance (10%). Pefloxacin, ciprofloxacin, septrin, and sparfloxacin were identified as the most potent antibiotics. The findings suggest that L. sulphureus has potential as an antibacterial agent, though its effectiveness varies according to extract concentration and bacterial species.