Multi-omics analysis reveals the heterogeneity and interactions among stromal and tumor cells in gastric cancer
This study highlights the critical role of CAFs and SMCs heterogeneity and their interactions within the GC TME (Tumor microenvironment). Targeting stromal pathways such as PDGF, TGF-β, and NF-κB signaling, immunomodulating CAFs, and disrupting SMC-derived vascular niches may improve therapeutic responses. Further experimental validation of ligand-receptor pairs and spatial determinants is warranted.
Authors
- Lingyi Zhou (ORCID: https://orcid.org/0000-0003-4774-8051)
- Xiaoyi Zhao (ORCID: https://orcid.org/0000-0003-0630-6230)
- Qiang Zhan (ORCID: https://orcid.org/0000-0002-2618-5475)
- Xin-Rong Xu (ORCID: https://orcid.org/0000-0003-2047-7298)
- Qinglin Zhang (ORCID: https://orcid.org/0000-0003-3942-7469)
- Yue Jin (ORCID: https://orcid.org/0000-0002-4154-5491)
- Chenyu Yang (ORCID: https://orcid.org/0009-0003-2017-6134)
Institutions
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1016/j.tranon.2025.102614
- Citations
- 1
- Primary Topic
- TGF-β signaling in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81