Radiation-induced lymphopenia: A data compilation to unveil relevant factors and mitigation strategies
This work establishes a comprehensive, quantitative foundation for understanding RIL. The developed ALC database supports mechanistic investigation and enables model-based approaches to predict lymphocyte dynamics, guiding the design of lymphocyte-sparing treatment strategies, including particle therapy.
Authors
- Jiří Kubeš (ORCID: https://orcid.org/0000-0002-4785-7306)
- Marco Durante (ORCID: https://orcid.org/0000-0002-4615-553X)
- Thomas Friedrich (ORCID: https://orcid.org/0000-0003-0074-6390)
- Sarah Al-Hamami (ORCID: https://orcid.org/0000-0002-1766-4482)
- Vladislav Sandul
Institutions
- GSI Helmholtz Centre for Heavy Ion Research (DE)
- Charles University (CZ)
- Technische Universität Darmstadt (DE)
- Proton Therapy Centre (CZ)
Publication Details
- Journal
- Clinical and Translational Radiation Oncology
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1016/j.ctro.2025.101071
- Citations
- 1
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.05