Decoding the effect of Diceratella elliptica on the oxidative stress–Inflammation axis in hyperthyroid-induced hepatotoxicity
Diceratella Elliptica exerts potent hepatoprotective activity against hyperthyroidism-induced hepatic injury. Its concurrent activation of SIRT1 and Nrf2, along with suppression of NF-κB-mediated inflammation and Caspase-3-dependent apoptosis, suggests modulation of the oxidative stress-inflammation-apoptosis axis. These findings support Diceratella Elliptica as a promising natural therapeutic candidate for thyroid-related liver dysfunction.
Authors
- Ahmed M. Ashour (ORCID: https://orcid.org/0000-0002-2118-0499)
- Nievin Ahmed Mahran (ORCID: https://orcid.org/0000-0001-9680-7594)
- Ali Khames
- Mohamed H. A. Gadelmawla (ORCID: https://orcid.org/0000-0002-1976-9480)
- Alzahraa A. Elhemiely (ORCID: https://orcid.org/0000-0003-1835-5806)
- Fatma F. El-Gneady
- Marwa A. Mahmoud (ORCID: https://orcid.org/0000-0002-4057-0097)
- Khaled M. Alam-ElDein (ORCID: https://orcid.org/0009-0002-1140-8338)
- Fahad S Ashehri
Institutions
- Sinai University (EG)
- Umm al-Qura University (SA)
- Desert Research Center (EG)
- Egyptian Government (EG)
- Badr University in Cairo (EG)
- Sohag University (EG)
Publication Details
- Journal
- Journal of Genetic Engineering and Biotechnology
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1016/j.jgeb.2025.100625
- Citations
- 1
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 1.56