A device for simultaneous neural recording and drug infusion in rodents

Here we present and validate an open-source motorized swivel which allows simultaneous neural and behavioral recording from rodents during drug infusion experiments. Cable and drug line tangling represents a limiting factor for neural recordings in freely moving rodents. This limits the scope of experiments that can be carried out using currently available commutators. The proposed device offers a cost-effective solution to the problem of cable twisting and line tangling during experiments in freely moving rodents, enabling in vivo recordings for new experimental paradigms such as drug self-administration. Additionally, it requires minimal human supervision, simplifying the experimental design pipeline and facilitating scalability. To demonstrate the usefulness and functionality of the device, we performed in vivo miniscope imaging in rat during a drug self-administration task, showing individual neurons' response to drug seeking and consumption.