Impact of sex on efficacy and safety of 1st-line treatment with FOLFIRI plus cetuximab or bevacizumab in RAS/BRAF wildtype metastatic colorectal cancer – A subgroup analysis of the FIRE-3 (AIO KRK-0306) trial
The exploratory analysis of FIRE-3 suggests that the efficacy of cetuximab combined with FOLFIRI in RAS wild-type mCRC is related to sex and primary tumor sidedness. The results support the inclusion of patient sex into the design of future trials.
Authors
- Markus Moehler (ORCID: https://orcid.org/0000-0003-4071-8562)
- Alexander Kiani (ORCID: https://orcid.org/0000-0002-2494-4087)
- Sebastian Stintzing (ORCID: https://orcid.org/0000-0002-3297-5801)
- Thomas Decker (ORCID: https://orcid.org/0000-0003-3814-8775)
- Julian Walter Holch (ORCID: https://orcid.org/0000-0002-4755-0179)
- Andreas Werner Jung (ORCID: https://orcid.org/0000-0003-3068-3212)
- Dominik Paul Modest (ORCID: https://orcid.org/0000-0002-6853-0599)
- Christoph Lerchenmüller
- Swantje Held (ORCID: https://orcid.org/0000-0002-1344-9056)
- Kathrin Heinrich (ORCID: https://orcid.org/0000-0003-3580-2313)
- Christoph Kahl (ORCID: https://orcid.org/0000-0002-9370-5928)
- Salah‐Eddin Al‐Batran (ORCID: https://orcid.org/0000-0002-0279-8509)
- Tobias Heintges
- Florian Kaiser (ORCID: https://orcid.org/0000-0002-5844-1779)
- Ludwig Fischer von Weikersthal (ORCID: https://orcid.org/0000-0002-9128-0807)
- Werner Scheithauer
- G. Seipelt
- Frank Kullmann
- Volker Heinemann
Institutions
- Goethe University Frankfurt (DE)
- German Cancer Research Center (DE)
- Johannes Gutenberg University Mainz (DE)
- University of Applied Sciences Landshut (DE)
- Heidelberg University (DE)
- Bayreuth Medical Center (DE)
- LMU Klinikum (DE)
- Comprehensive Cancer Center Vienna (AT)
- Ravensburg University of Cooperative Education (DE)
- German Cancer Society (DE)
- Klinikum Magdeburg (DE)
- Klinikum Weiden (DE)
- Institute of Clinical Cancer Research (DE)
- AIO Studien gGmbH (DE)
- University Hospital Frankfurt (DE)
- Krankenhaus Nordwest (DE)
- Lukaskrankenhaus (DE)
- Comprehensive Cancer Center Erlangen (DE)
- Klinikum St. Marien Amberg (DE)
- Medical University of Vienna (AT)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1016/j.ejca.2025.116133
- Citations
- 1
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.05