FBXO22-mediated ubiquitination of KLF10 promoting pancreatic cancer proliferation and invasion
FBXO22 promotes pancreatic cancer progression by mediating KLF10 ubiquitination and degradation, thereby impairing its tumor-suppressive functions. FBXO22 may serve as a potential oncogenic and therapeutic target associated with pancreatic cancer progression.
Authors
- Fenfen Jiang (ORCID: https://orcid.org/0000-0001-8282-3059)
- Xiaoguang Wang (ORCID: https://orcid.org/0000-0002-7726-0906)
- Xuesong He
- Xiaorong Liu (ORCID: https://orcid.org/0000-0002-5278-7189)
- Yuan Xue (ORCID: https://orcid.org/0000-0002-7457-714X)
- Yuanmin Hu
Institutions
- Zhejiang Chinese Medical University (CN)
- Chifeng University (CN)
- Jiaxing University (CN)
- First Hospital of Jiaxing (CN)
Publication Details
- Journal
- Pancreatology
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1016/j.pan.2025.11.016
- Citations
- 1
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.81