Emergence of KL57 hypervirulent Klebsiella pneumoniae in Wuxi, China: Genomic insights into virulence plasmid evolution and blaKPC-2-bearing IncFIIK34 plasmid transmission
Our study corroborates the widespread occurrence of the ST412 KL57 K. pneumoniae in China and identifies a specific strain harboring the IncFII<sub>K34</sub> resistance plasmid. Additionally, the KL57 CRKp strain carries a variety of carbapenemase genes, and some of these strains simultaneously harbor multiple such genes. Our findings suggest that this subtype demonstrates enhanced resistance adaptability and may facilitate the dissemination of drug resistance through horizontal gene transfer. Consequently, it is necessary to develop more targeted surveillance strategies that focus on resistance gene characteristics and prevalent subtypes.
Authors
- Lin Wan (ORCID: https://orcid.org/0000-0002-3511-0512)
- Yutong Liu (ORCID: https://orcid.org/0009-0004-9263-1869)
- Xiong Li (ORCID: https://orcid.org/0000-0001-6147-1090)
- Renjing Hu (ORCID: https://orcid.org/0000-0001-6631-1643)
Institutions
- Jiangnan University (CN)
- Southwest Medical University (CN)
- Wuxi No.2 People's Hospital (CN)
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- International Journal of Medical Microbiology
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1016/j.ijmm.2025.151687
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00