Photocatalytic Intramolecular Aminocarboxylation of Alkenes with Atmospheric CO <sub>2</sub> : Diastereoselective Access to β-Homoproline Derivatives
β-Homoproline derivatives are valuable scaffolds in biologically active molecules and pharmaceuticals. However, efficient methods for synthesizing α-substituted β-homoproline derivatives remain underdeveloped. We report a photoredox-catalyzed intramolecular aminocarboxylation of alkenes using atmospheric CO<sub>2</sub> under mild conditions. This transformation provides a broad range of α-substituted β-homoprolines in good to excellent yields (up to 93%) and high diastereoselectivity (up to 12:1). The synthetic utility of the products was demonstrated through various downstream transformations.
Authors
- Hohjai Lee (ORCID: https://orcid.org/0000-0002-6810-0206)
- Hyeongyeol Oh (ORCID: https://orcid.org/0000-0003-2057-7926)
- Seung-Chul Park
- Sukwon Hong (ORCID: https://orcid.org/0000-0002-2078-9630)
- Kai Lang (ORCID: https://orcid.org/0000-0003-2778-8478)
- Hyungwoo Hahm (ORCID: https://orcid.org/0000-0003-3092-2906)
Institutions
- Gwangju Institute of Science and Technology (KR)
- Heilongjiang University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1021/acs.joc.5c02587
- Primary Topic
- Carbon dioxide utilization in catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00