Integrated mendelian randomization and bioinformatics approach unveiling the immunological and prognostic significance of FBXO2 in breast cancer
In conclusion, our comprehensive analysis revealed that FBXO2 plays a critical tumor-suppression role in BRCA, with its down-regulation contributing to poor prognosis. Furthermore, FBXO2 was implicated in immune regulation and tumor microenvironment remodeling. Our findings provided novel insights into the pathogenesis of BRCA.
Authors
- Rongzhi Huang (ORCID: https://orcid.org/0000-0003-2773-6635)
- Zhibai Chen
- Min Mao (ORCID: https://orcid.org/0000-0002-0139-1723)
- Jiehua Li (ORCID: https://orcid.org/0000-0002-7244-3631)
- Shenglian Lai
Institutions
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1007/s12672-025-04130-6
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00