The nuclear localization sequence and C-terminus of parathyroid hormone-related protein regulate chondrocyte development in epiphyseal growth cartilage
Loss of the PTHrP (67 -139) domain causes impaired proliferation, reduced matrix production, and increased extracellular matrix degradation in epiphyseal chondrocytes. These findings demonstrate that PTHrP (67 -139) is required to maintain chondrocytes in an immature state and that its absence leads to premature differentiation of epiphyseal growth plate chondrocytes.
Authors
- Rachelle W. Johnson (ORCID: https://orcid.org/0000-0003-2755-9851)
- Waleed J. Hashmi
- Noriko Kantake
- Ramiro E. Toribio (ORCID: https://orcid.org/0000-0002-9063-540X)
- Shouan Zhu (ORCID: https://orcid.org/0000-0002-4973-1504)
- Thomas J. Rosol (ORCID: https://orcid.org/0000-0003-3737-1190)
- Blake E. Hildreth (ORCID: https://orcid.org/0000-0002-4631-1117)
- Nathan K. Hoggard (ORCID: https://orcid.org/0000-0003-2202-7506)
- Ibiagbani M. Max-Harry (ORCID: https://orcid.org/0000-0002-5126-4562)
- Jeremy Kane
Institutions
- Florida State University (US)
- Vanderbilt University (US)
- University of Alabama at Birmingham (US)
- Ohio University (US)
- The Ohio State University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Connective Tissue Research
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1080/03008207.2025.2571548
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00